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Mitochondrial inhibitors and neurodegenerative disorders

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Published by Humana Press in Totowa, N.J .
Written in English


  • Nervous system -- Degeneration -- Pathophysiology,
  • Nervous system -- Degeneration -- Animal models,
  • Mitochondrial pathology,
  • Neurotoxic agents,
  • Neurodegenerative Diseases -- chemically induced,
  • Propionic Acids -- toxicity,
  • Mitochondria -- metabolism,
  • Neurotoxins -- toxicity

Book details:

Edition Notes

Includes index.

Statementedited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan.
SeriesContemporary neuroscience
ContributionsSanberg, Paul R., Nishino, Hitoo., Borlongan, Cesario V.
LC ClassificationsRC394.D35 M56 2000
The Physical Object
Paginationxvii, 313 p. :
Number of Pages313
ID Numbers
Open LibraryOL390120M
ISBN 10089603805X
LC Control Number98055467

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In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3.   This book undoubtedly gives a detailed account of 3-NP and serves an important function in bringing together a wide range of authors and a comprehensive review of this chemical. However, the book does not fulfil the purpose of its title, which is to cover mitochondrial inhibitors and neurodegenerative disorders in : A. Schapira.   Read "Mitochondrial Inhibitors and Neurodegenerative Disorders" by available from Rakuten Kobo. Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infe Brand: Humana Press. Mitochondrial Inhibitors and Neurodegenerative Disorders details one such toxin, 3-nitropropionic acid (3-NPA), an irreversible inhibitor of succinate dehydrogenase, and its use in experimental models of central nervous system neurotoxicity and neurodegenerative diseases like Huntington's disease (HD).Author: William S. Musser.

Mitochondrial Inhibitors and Neurodegenerative Disorders --Foreword --Preface --Contents --Contributors --PART I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal.   Book review Mitochondrial inhibitors and neurodegenerative disorders, by P.R. Sanberg, H. Nishino, C.V. Borlongon, (eds.), Humana Press, New Jersey, ISBN X, pp. , $ It is only in the past one or two decades that the essential role of the mitochondrion in the pathogenesis of neurodegenerative diseases has been recognised. In the â s the effects of . This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Mitochondrial Inhibitors and Neurodegenerative Disorders Contemporary Neuroscience: : Sanberg, Paul R., Borlongan, Cesario V., Nishino, Hitoo: Books Select Your Cookie Preferences We use cookies and similar tools to enhance your shopping experience, to provide our services, understand how customers use our services so we can make Format: Hardcover.

  Irreversible injury to mitochondria is a cornerstone of pathogenesis of neurological diseases. Therefore, given the critical role of these organelles in disease . Purchase Mitochondrial Disorders in Neurology - 1st Edition. Print Book & E-Book. ISBN , This chapter reviews the evidence for the contribution of mitochondrial dysfunction in neurodegenerative disorders and explores potential mechanisms to circumvent the defects responsible. The respiratory chain and oxidative phosphorylation system comprise five multisubunit protein complexes and two mobile electron carriers located on the. Mitochondrial toxins are capable of producing relatively selective neuronal cell death and have been used to produce models of human neurodegenerative diseases e.g. 1-methyl 4-phenyl 1,2,3,6 tetrahydropyridine (MPTP) for Parkinson's disease, and 3-nitropropionic acid for Huntington's disease.