|Statement||edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan.|
|Contributions||Sanberg, Paul R., Nishino, Hitoo., Borlongan, Cesario V.|
|LC Classifications||RC394.D35 M56 2000|
|The Physical Object|
|Pagination||xvii, 313 p. :|
|Number of Pages||313|
|LC Control Number||98055467|
In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3. This book undoubtedly gives a detailed account of 3-NP and serves an important function in bringing together a wide range of authors and a comprehensive review of this chemical. However, the book does not fulfil the purpose of its title, which is to cover mitochondrial inhibitors and neurodegenerative disorders in : A. Schapira. Read "Mitochondrial Inhibitors and Neurodegenerative Disorders" by available from Rakuten Kobo. Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infe Brand: Humana Press. Mitochondrial Inhibitors and Neurodegenerative Disorders details one such toxin, 3-nitropropionic acid (3-NPA), an irreversible inhibitor of succinate dehydrogenase, and its use in experimental models of central nervous system neurotoxicity and neurodegenerative diseases like Huntington's disease (HD).Author: William S. Musser.
Irreversible injury to mitochondria is a cornerstone of pathogenesis of neurological diseases. Therefore, given the critical role of these organelles in disease . Purchase Mitochondrial Disorders in Neurology - 1st Edition. Print Book & E-Book. ISBN , This chapter reviews the evidence for the contribution of mitochondrial dysfunction in neurodegenerative disorders and explores potential mechanisms to circumvent the defects responsible. The respiratory chain and oxidative phosphorylation system comprise five multisubunit protein complexes and two mobile electron carriers located on the. Mitochondrial toxins are capable of producing relatively selective neuronal cell death and have been used to produce models of human neurodegenerative diseases e.g. 1-methyl 4-phenyl 1,2,3,6 tetrahydropyridine (MPTP) for Parkinson's disease, and 3-nitropropionic acid for Huntington's disease.